Jessica Tyler

Jessica Tyler is a Professor at Weill Cornell Medicine, New York City, where she heads the Laboratory of Epigenetics and Genome Integrity.

Her research focuses on the regulation of genomic processes by chromatin structure and mechanisms of replicative aging, using budding yeast as a model system for the aging of stem cells in humans. During her postdoctoral studies with Dr. James Kadonaga at the University of California, San Diego, she identified the key chromatin assembly factors Anti-silencing Function 1 (Asf1) and characterized Chromatin Assembly Factor 1 (CAF-1) from Drosophila.

Dr. Tyler’s earlier work revealed that chromatin assembly and disassembly not only regulates S phase events, but also gene expression and the DNA damage response. Her finding that yeast lacking these chromatin assembly factors have altered lifespans led her to uncover that histone levels drastically decrease during aging, and is a cause of aging. Their lab has subsequently uncovered other changes that drive the aging process.

​Dr. Tyler was a Leukemia and Lymphoma Society Scholar and was awarded the Tenovus Medal and the Charlotte Friend Woman in Cancer Research Award from the American Association of Cancer Research (AACR).

Dr. Tyler was a speaker at the 2020 Undoing Aging Conference event.